在治疗耐药性抑郁症中,在psilocybin辅助治疗后的认知结果:对随机等候名单对照试验的后期分析
Danica E Johnson1, Shakila Meshkat2, Erica S Kaczmarek3
1Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Progress in neuro-psychopharmacology & biological psychiatry
|November 24, 2025
概括
松素辅助心理治疗 (PAP) 在治疗耐药性抑郁症 (TRD) 的处理速度和执行功能方面显示出适度的,短期的认知改善. 这些益处独立于情绪,但并没有显著超过实践效应,需要进一步的受控研究.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 认知缺陷在耐治疗抑郁症 (TRD) 和耐治疗双极性抑郁症 (TRBD) 中很常见,通常对标准治疗无反应.
- 松素辅助心理治疗 (PAP) 是TRD的一个有前途的新型干预措施,但其对这一群体的认知效应需要进一步研究.
研究的目的:
- 为了评估psilocybin辅助心理治疗 (PAP) 对治疗耐药单极和双极抑郁症 (TRD/TRBD) 的成年人认知功能的影响.
主要方法:
- 对26名TRD/TRBD成年人进行了回顾性分析,他们接受了PAP.
- 使用数字符号替代测试 (DSST) 和Trail Making Test (TMT) 部分A和B在基线,一天和治疗后两周测量认知表现.
- 使用线性混合模型和可靠的变化指数来分析随时间推移认知表现的变化.
主要成果:
- 随着时间的推移,在TMT-A,TMT-B和TMT-B减去TMT-A得分中观察到显著的改善 (p < .05),即使在调整抑郁症状后也是如此.
- 在DSST得分的改善没有统计学意义 (p = .069).
- 可靠的变化指数表明,4.2%-12.5%的参与者实现了有意义的认知改善,但这并没有明显超过机会.
结论:
- 在TRD患者中,PAP与处理速度和执行功能的适度,短期改善有关.
- 观察到的认知变化似乎独立于情绪改善,但并不总是超过实践效应.
- 需要进一步进行足够的强化,有控制的试验,以确定这些认知变化是psilocybin的真正的认知效应,还是由于非特异性因素.
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