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在患有晚期膝关节关节炎和II-III类肥胖症的患者中,sarcopenic肥胖的患病率和临床影响
K Godziuk1, F T Vieira2, M Forhan3
1Department of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, AB, Canada; Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, USA.
麻性肥胖 (SO) 影响28%的膝关节骨关节炎 (OA) 和肥胖的成年人,导致身体功能和生活质量降低. 早期识别SO对于个性化干预至关重要.
科学领域:
- 老年学是一门学科.
- 整形外科 整形外科 整形外科
- 代谢健康 代谢健康
背景情况:
- 肥胖症 (SO) 的特点是肌肉质量和功能低,与脂肪质量高相结合.
- 患有晚期膝关节关节炎 (OA) 和肥胖 (BMI ≥35 kg/m2) 的个人有增加SO的风险.
- SO显著影响移动性,发病率和整体生活质量.
研究的目的:
- 为了确定患有膝关节骨质炎和肥胖症的成年人中SO的患病率.
- 为了比较SO的不同诊断标准.
- 检查SO对该人口的身体功能和生活质量的影响.
主要方法:
- 从POMELO试点试验的基线数据进行横截面分析.
- SO诊断基于低肌肉功能,低肌肉质量和高脂肪质量的标准.
- 评估包括手握强度,椅子坐立,身体组成的DXA,Euroqol EQ-5D,6分钟步行测试 (6MWT) 和WOMAC.
主要成果:
- 在50名参与者中,28% (74%为女性,平均BMI为42.1kg/m2) 符合SO标准.
- 患有SO的个体表现出明显较短的6MWT距离 (-78.6m,p=0.012).
- SO与较差的WOMAC功能得分 (7.2,p=0.046) 和较低的EQ-5D视觉模拟得分 (-14.7,p=0.016) 相关.
结论:
- 在患有肥胖症的膝关节OA患者中,sarcopenic肥胖症很普遍 (28%).
- SO与身体功能和生活质量的临床显著下降有关.
- 识别SO可以指导膝关节OA患者的个性化管理策略,可能是在减肥干预或手术之前.
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