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两种不同延长释放的梅洛西卡姆配方对减轻大鼠 (Rattus norvegicus) 过敏的止痛作用

Yufei Ge¹, Eden D Alamaw¹, Katechan Jampachaisri²

¹Department of Comparative Medicine, Stanford University, Stanford, California.

Journal of the American Association for Laboratory Animal Science : JAALAS

|November 24, 2025

概括

延长释放的梅洛西卡姆 (Melox-ER,Melox-XR) 和标准的梅洛西卡姆 (Melox) 在老鼠的切口疼痛方面进行了比较. 梅洛克斯和梅洛克斯-XR在48小时后都显示出止痛作用,但需要对老鼠的梅洛克萨姆剂量进行进一步的研究.

科学领域:

兽医医学兽医医学兽医医学
药理学药理学是指药理学的学科.
疼痛管理疼痛管理

背景情况:

梅洛西卡姆是一种常见的非类固醇抗炎药物 (NSAID),用于治疗动物疼痛.
延长释放配方旨在改善剂量频率和治疗持续时间.
在动物模型中评估镇痛功效对于疼痛管理研究至关重要.

研究的目的:

为了比较两种延长释放的梅洛西卡姆配方与标准配方在老鼠切口疼痛模型中的止痛效果.
为了评估不同配方的麻醉剂效果的持续时间.
确定最佳的梅洛西卡姆剂量策略,以治疗动物手术后疼痛.

主要方法:

成年大鼠接受了盐水,标准的梅洛西卡姆 (Melox),梅洛西卡姆延长释放聚合物 (Melox-ER) 或梅洛西卡姆延长释放悬浮剂 (Melox-XR).
在麻醉下诱导了切口疼痛模型.
机械和热过敏性在手术前和手术后72小时内被评估.

主要成果:

盐水组表现出机械和热过敏.
梅洛克斯-ER在任何时间点都没有显示出显著的止痛作用.
在手术后48小时,Melox和Melox-XR都在减少机械过敏症方面表现出有效性.
在所有接受梅洛西卡姆治疗的组中观察到注射部位反应.

结论:

标准的梅洛西卡姆和Melox-XR配方在48小时后为机械过敏症提供了相似的止痛效果.
在这种老鼠切口疼痛模型中,Melox-ER配方没有有效.
需要进一步的研究来确定最佳的梅洛西卡姆剂量,以治疗老鼠的切口疼痛.

关键词:

梅洛克斯,梅洛西卡姆在2毫克/公斤.梅洛克斯-ER,梅洛西卡姆延长释放聚合物梅洛克斯-XR,梅洛西卡姆延长释放悬浮剂

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