链接的EHR-药房数据和行政索赔数据的比较:怀孕期间的药物填充剂
Gregory P Jansen1, Gabriela Vazquez-Benitez2, Kirsten Ehresmann2
1Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.
Pharmacoepidemiology and drug safety
|November 24, 2025
概括
链接的电子健康记录 (EHR) 和药房数据发现,怀孕期间的药物填充量比索赔数据更多. 这表明链接的EHR-药房数据为围产期药物安全性研究提供了更全面的资源.
科学领域:
- 围产期健康 围产期健康
- 药学流行病学 药学流行病学
- 医疗信息学 医疗信息学
背景情况:
- 关于怀孕期间药物安全性的研究传统上使用医疗保险索赔数据,这些数据可能缺乏详细的临床信息.
- 电子健康记录 (EHR) 提供了更丰富的临床细节,并将其与药房数据联系起来,可以捕获药物填充记录,从而提高它们对研究的有用性.
研究的目的:
- 为了比较连接的EHR-药房数据库和怀孕期间使用的常见药物的传统索赔数据之间的药物填充数据.
- 评估这两种数据来源之间的一致性和流行率差异,以研究围产期药物使用.
主要方法:
- 在明尼苏达州医疗保健系统中,使用链接的EHR-药房数据和12440例怀孕 (2017-2021) 的索赔数据进行了比较分析.
- 对27种常见药物的流行差异和一致性 (百分比一致性,科恩 κ) 进行了评估.
- 此外,还评估了两种数据来源之间的药物填充时间.
主要成果:
- 链接的EHR-药房数据显示,与索赔数据相比,药物填充的患病率略高,最大患病率差异为1.5%.
- 在这两种数据源之间观察到很高的一致性,百分比一致性超过97%和所有药物的科恩 κ ≥ 0.870.
- 与反向比较相比,更多的人在第一次填充后的±1天内记录了链接的电子病历-药房数据中的药物填充.
结论:
- 链接的EHR-药房数据提供了比单独的索赔数据更全面的怀孕期间药物填充记录.
- 高级协议表明,链接的EHR-药房数据是围产期药物安全研究的有价值和潜在的更完整的资源.
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