重组功能网络是右半球中风后工作记忆缺陷的基础
Emilie Marti1, Sélim Yahia Coll1, Naz Doganci1
1Research Group Spatial Attention, Perception and Action, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
The European journal of neuroscience
|November 24, 2025
概括
脑卒中患者由于大脑网络连接中断而表现出工作记忆 (WM) 损伤. 右半球 (RH) 脑区域内连接性减少与WM较差相关,而半球之间的连接性增加表明补偿.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经学 神经学
背景情况:
- 工作记忆 (WM) 对认知至关重要,但中风往往会损害它.
- 传统的病变映射错过了大规模的大脑网络变化影响WM中风后.
研究的目的:
- 使用功能连接 (FC) 分析,调查右半球 (RH) 中风患者的工作记忆 (WM) 缺陷.
- 在RH中风中幸存者中检查前端双网络FC和WM表现之间的关系.
主要方法:
- 在34名RH中风患者和35名对照患者中利用静止状态fMRI进行种子-到-voxel FC分析.
- 使用口头和空间N-back任务评估WM性能.
- 与WM任务准确性相关的FC测量.
主要成果:
- 与对照组相比,中风患者表现出改变的FC-WM关联.
- 在RH中减少的内半球FC与较低的WM性能相关.
- 增强的半球间FC与WM准确性呈现出积极的关联,表明了补偿机制.
结论:
- 脑卒中后的工作记忆缺陷是由于大脑网络动态的改变造成的,而不仅仅是焦点损伤.
- 减少的内半球连接可以通过内半球招聘来补偿.
- 这些发现强调了早期网络重组在中风后认知恢复中的作用.
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