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研究人员发起的临床试验招生前线大B细胞淋巴瘤的障碍

Carrie Ho¹, Neena Kennedy², Mengyang Di²

¹Department of Internal Medicine, Division of Hematology and Oncology, University of California San Francisco, San Francisco, CA.

Clinical lymphoma, myeloma & leukemia

|November 24, 2025

概括

地理距离和邻里贫困限制了大B细胞淋巴瘤 (LBCL) 患者的临床试验招生. 解决这些障碍对于公平获得癌症研究和改善患者治疗结果至关重要.

科学领域:

在瘤学瘤学.
临床试验临床试验
健康公平卫生公平

背景情况:

前线疗法治疗大约75%的大B细胞淋巴瘤 (LBCL) 患者,需要进行临床试验以改善结果.
由于后勤和结构障碍,临床试验的招生受到阻碍.
我们中心的研究人员发起的试验 (IIT) 显示患者招募速度比行业赞助的试验快,但地理和社会经济影响尚不清楚.

研究的目的:

调查地理和社会经济地位对前线研究人员发起的大型B细胞淋巴瘤 (LBCL) 临床试验 (IITs) 患者招募的影响.
确定人口,地理和社会经济预测试验资格和LBCL患者的招生因素.

主要方法:

在2022年10月至2024年6月期间,对新诊断的LBCL的成年人进行回顾性审查,并将其转移到弗雷德·哈森癌症中心 (FHCC).
数据收集包括人口统计,FHCC的地理距离,地区贫困指数 (ADI),保险和口译需求.
使用后勤和弹性净回归分析来评估试验招生预测因素.

主要成果:

在153名符合条件的患者中,有24名 (35%) 接受前线IIT.
与非注册的合格患者相比,注册的患者生活在FHCC (中位数为15与50英里) 显著更接近,并且具有较低的ADI得分 (中位数为8与21).
地理距离和ADI是招生的重要预测因素,在多变量分析中,距离仍然很重要.

结论:

地理距离和社区贫困对LBCL研究员发起的试验 (IIT) 的招生产生重大影响.
分散的试验模型,远程医疗和系统级干预措施对于缓解这些不平等至关重要.
减少参与障碍可以改善不同患者群体获得新型癌症治疗的机会.

关键词:

访问访问访问访问访问.临床试验中的临床试验.地理地理地理地理.在健康方面存在差异.社会经济地位社会经济地位

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