子宫内微生物组 - 神经发育轴:解码产前微生物印记对终身心理健康的影响
Wiku Andonotopo1, Muhammad Adrianes Bachnas2, Julian Dewantiningrum3
1Fetomaternal Division, Women Health Center, Department of Obstetrics and Gynecology, 648394 Ekahospital BSD City , Tangerang, Banten, Indonesia.
Journal of perinatal medicine
|November 24, 2025
概括
母亲的微生物组通过免疫,代谢和表观遗传途径影响胎儿的大脑发育. 修改母亲的微生物组有可能预防神经发育障碍,如自闭症谱系障碍 (ASD) 和注意力缺陷/多动症障碍 (ADHD).
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 发展生物学 发展生物学
背景情况:
- 关于无菌子宫的传统观点受到胎盘和胎儿组织中微生物DNA检测的挑战.
- 孕产妇的微生物群信号可能会影响胎儿大脑发育和长期神经心理健康.
研究的目的:
- 审查关于母亲微生物群与胎儿大脑相互作用的临床前和临床证据.
- 探索免疫,代谢和表观遗传机制,将母体微生物与胎儿神经发育联系起来.
主要方法:
- 对90多项临床前和临床研究的叙述性综述.
- 分析有关母亲免疫激活,微生物代谢物和表观遗传变化的数据.
- 检查产前因素和神经发育障碍之间的流行病学联系.
主要成果:
- 母体免疫激活 (例如IL-6,IL-17A) 破坏小鼠胎儿皮层发育.
- 孕产妇的炎症与人类队伍中自闭症谱系障碍 (ASD) 风险增加有关.
- 胎盘/带血中的微生物代谢物和表观遗传变化与产前条件和神经发育结果有关.
结论:
- 母亲微生物群通过免疫,代谢,表观遗传和激素途径影响胎儿大脑发育.
- 动物模型提供了机械洞察力,但人类数据主要是观察性的.
- 修改母亲的微生物组为预防神经发育障碍提供了机会,需要临床验证.
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