单细胞基因组学揭示了状动物和状虫中的复杂微生物和病毒关联
Frederik Schulz1, Ying Yan2, Agnes K M Weiner2,3
1DOE Joint Genome Institute, Berkeley, California, USA. fschulz@lbl.gov.
Nature communications
|November 24, 2025
概括
质体是多种多样的细菌共生体和病毒的宿主,揭示了复杂的微生物生态系统. 这项研究探讨了这些隐藏的合作伙伴,揭示了独特的微生物组结构和原生体内的多方相互作用.
科学领域:
- 微生物学 微生物学
- 生态生态学 生态生态学
- 基因组学就是基因组学.
背景情况:
- 原生体对于营养循环至关重要,但它们的相关微生物组尚未得到充分研究.
- 了解原生菌-微生物-病毒相互作用是生态系统功能的关键.
研究的目的:
- 为了研究未经培养的状动物和虫的微生物组和病毒组.
- 描述微生物共生体和与原生体相关的病毒的多样性和功能.
主要方法:
- 使用培养独立的单细胞隔离.
- 采用基因组解析的元基因组学来分析微生物群落.
- 从各种环境样本中研究了原生体微生物组和病毒组.
主要成果:
- 发现了独特的微生物组结构,在状动物和虫之间有明显的差异.
- 恢复了众多微生物基因组,包括已知的内共生生物和宿主相关细菌,许多显示基因组缩小和适应细胞内生活方式.
- 识别了80多种巨型病毒和其他病毒系,有活跃基因表达和潜在的多方相互作用的证据.
结论:
- 原生体作为微生物和病毒协会的中心枢纽.
- 该研究提供了对原生相关微生物和病毒的多样性,活动和生态意义的全面了解.
相关概念视频
Diversity of Protists II
754
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
754
Diversity of Protists I
819
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
819
Diversity of Protists IV
720
Amoebozoa represent a diverse group of terrestrial and aquatic protists that utilize lobe-shaped pseudopodia for locomotion and feeding. This characteristic differentiates them from the Rhizaria, which possess threadlike pseudopodia. The primary classifications within Amoebozoa include gymnamoebas, entamoebas, and the plasmodial and cellular slime molds. Phylogenetic evidence indicates that Amoebozoa diverged from a lineage that ultimately gave rise to fungi and animals.Gymnamoebas and...
720
Types of Microorganisms
1.6K
Microorganisms are a diverse group of microscopic entities broadly categorized into cellular and acellular types based on their structural organization. Cellular microorganisms include bacteria, archaea, fungi, protozoa, and algae, while acellular microorganisms are represented by viruses.Cellular MicroorganismsBacteriaBacteria, tiny prokaryotic organisms, exhibit fascinating shapes such as rods, spheres, and spirals. They adapt to diverse habitats, including soil, water, and human-associated...
1.6K
Modern Molecular Taxonomy
554
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
554
Viruses of Archaea
429
Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
429


