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Updated: Jul 24, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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抑制RNaseH2增强了患者衍生质母细胞细胞中的temozolomide反应

Miroslava Kissova1, Judit Martinez Segarra1, Tobias Solli Iveland1,2

  • 1Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology NTNU, Trondheim, 7491, Norway.

Scientific reports
|November 25, 2025
PubMed
概括

抑制RNaseH2可能会改善质母细胞瘤治疗. 将RNaseH2抑制剂与temozolomide结合在患者衍生模型中显示出有希望的结果,可能会改善这种侵袭性脑癌的结果.

关键词:
药物查是指对药物进行查.在GBMGBMGBMGBMGBM高通量选 (HTS) 是一种高通量选.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...