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Updated: Jan 10, 2026

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

Published on: February 3, 2022

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对于蛋白质工程的SpCas9中内部域替换的结构和功能洞察力

Seonhong Kim1, Hyuk Won2, Jungnam Bae1

  • 1Department of Biological Sciences, Seoul National University, Seoul, 08826, Republic of Korea.

Scientific reports
|November 25, 2025
PubMed
概括

研究人员通过将可用的C端区域替换为除氨酶域来设计CRISPR-Cas9. 这创建了一个多功能基础编辑器,具有可调节的编辑窗口,用于精确的基因组编辑应用程序.

关键词:
氨基基基编辑器 氨基基基编辑器克里斯普尔-Cas9是什么意思蛋白质工程是一种蛋白质工程.在X射线晶体学.

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