将肠道微生物群的节律与婴儿的昼夜成熟度联系起来
Christophe Mühlematter1, Dennis S Nielsen2, Josue L Castro-Mejía2
1Department of Psychology, University of Fribourg, Rue P.-A.-de-Faucigny 2, CH-1700, Fribourg, Switzerland.
Scientific reports
|November 25, 2025
概括
婴儿的肠道细菌节律在生命的第一年与睡眠模式同步. 这种同步,通过循环功能指数 (CFI) 来衡量,随着年龄的增长而加强,这表明了一个关键的发育窗口.
科学领域:
- 微生物学 微生物学
- 发展生物学 发展生物学
- 时间生物学 时间生物学
背景情况:
- 人的肠道微生物群每天都会出现波动,但其与婴儿睡眠和清醒模式的相互作用还不太清楚.
- 早期的微生物发育对长期健康至关重要,并可能影响昼夜系统的成熟.
研究的目的:
- 调查肠道微生物群节律性与婴儿在第一年睡眠和清醒模式的发展之间的关系.
- 为了确定微生物振荡是否与睡眠成熟标志物相关.
主要方法:
- 162名健康婴儿在3,6个月和12个月时使用动画和日记进行了监测.
- 用16S rRNA测序分析了肠道微生物组成.
- 微生物节律性通过 sinus 和 cosine 拟合进行评估; 睡眠-觉醒节律成熟度用循环功能指数 (CFI) 来量化.
主要成果:
- 显著比例的细菌类 (1.74%正弦,6.69%共弦) 显示了日常节奏模式.
- 肠道微生物群中的共弦律率随着年龄的增长而增加,表明成熟.
- 105种细菌种群 (7.02%) 与CFI有显著的关联,这种联系在第一年得到加强.
结论:
- 在婴儿期,肠道微生物群的节奏变得越来越与睡眠和清醒周期同步.
- 这种同步突出了肠-大脑轴成熟的关键发育时期.
- 研究结果表明,针对肠道微生物群的早期干预有可能改善婴儿的睡眠和发育.
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