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与乳酸代谢相关的差异性表达基因揭示了撒科佩尼亚背后的生物学机制

Yan Li¹, Zhenbin Xu²

¹Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, Fujian Province, China.

Scientific reports

|November 25, 2025

概括

肉症 (SARC) 涉及由于衰老而导致的肌肉损失. 这项研究确定了参与SARC的关键乳酸代谢基因,为这种与年龄相关的疾病提供了潜在的新诊断和治疗点.

科学领域:

基因组学就是基因组学.
衰老研究研究衰老研究
生物标志物发现发现

背景情况:

麻症 (SARC) 是一种与年龄相关的肌肉疾病,诊断和治疗选择有限.
对于有效的SARC管理,迫切需要新的生物标志物.
与乳酸代谢相关的基因与各种生理过程有关.

研究的目的:

研究与乳酸代谢相关的差异表达基因 (LMRDEGs) 在SARC中的作用.
确定关键的基因和与SARC病变发生相关的途径.
探索LMRDEGs作为SARC的诊断生物标志物的潜力.

主要方法:

对SARC中差异表达基因 (DEG) 的基因表达综合 (GEO) 数据库的分析.
基因组丰富分析 (GSEA) 用于途径识别.
使用STRING数据库构建蛋白质与蛋白质相互作用 (PPI) 网络.
通过基因本体学 (GO) 和基因和基因组 (KEGG) 途径分析的京都百科全书进行功能注释.
免疫透分析.

主要成果:

17种LMRDEG被确定为在SARC中受到显著的上调或下调.
丰富分析显示,LMRDEGs参与了代谢能量调节和细胞内信号转导.
免疫透分析表明,SARC样本中的免疫细胞丰度存在显著差异.

结论:

与乳酸代谢相关的差异性表达基因在肉症的发病过程中起着至关重要的作用.
这些LMRDEGs参与了关键的细胞过程,与SARC发展有关.
需要对LMRDEG进行进一步的研究,以了解它们作为SARC的治疗标和诊断生物标记物的潜力.

关键词:

不同表达的基因.基因本体学是基因的本体学.乳酸盐代谢乳酸代谢路径丰富方式萨尔科佩尼亚是什么意思萨尔科佩尼亚

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