相关实验视频
Updated: Jan 10, 2026

13:25
Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
6.5K
曼尼托尔与罗西米德用于预防西斯普拉丁诱导的毒性在一个多中心的回顾性队列研究
Yudai Harimitsu1,2, Toshinobu Hayashi3, Mototsugu Shimokawa4
1Department of Pharmacy, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
Scientific reports
|November 25, 2025
概括
在接受西斯普拉丁化疗的患者中,罗塞米德与曼尼托尔相比,表现出更好的脏保护,显著降低了毒性发病率和血清胆固醇升. 这表明罗西米德是一种可行的替代品,可以预防西斯普拉丁诱导的损伤.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
背景情况:
- 西斯 (cis-diamminedichloroplatinum [CDDP]) 化疗与显著的毒性有关.
- 使用曼尼托尔或罗塞米德的强制性尿液被用来减轻这种风险.
- 在CDDP疗法中对这些利尿剂的脏保护功效的比较数据有限.
研究的目的:
- 在接受基于CDDP的化疗的患者中,比较furosemide与mannitol的脏保护作用.
- 为了确定与CDDP诱导的毒性相关的风险因素.
主要方法:
- 在接受CDDP (≥60 mg/m2) 的472名癌症患者的多中心回顾性研究中.
- 患者接受了曼尼托尔或罗西米德作为强制性利尿剂.
- 使用常用术语标准对不良事件进行评估的毒性 (ver. 5.0);患者特征通过逆概率治疗权重来平衡.
主要成果:
- 与曼尼托尔组 (23.2%) 相比,罗塞米德组 (6.2%) 的毒性发病率较低 (p < 0.007).
- 富洛塞米德 (21.7%±19.3%) 的平均血清肌素增加明显低于曼尼托尔 (29.5%±40.7%) (p=0.007).
- 高血压,较高的CDDP剂量 (≥75 mg/m2),缺乏补充剂和曼尼托尔使用与毒性风险增加有关.
结论:
- 与基于CDDP的化疗中曼尼托尔相比,罗塞米德表现出更强的脏保护作用.
- 富洛塞米德为减轻西斯胺诱导的毒性提供了一种可行的治疗替代曼尼托尔.
- 建议通过大型随机对照试验进行进一步验证.
相关概念视频
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
224
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
224
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
220
Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
220
Imaging Studies V: Intravenous Urography and Retrograde Pyelography
995
IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
995
Renal Drug Clearance: Comparison Between Renal Excretion Methods
541
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
541

