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HDAC1具有内在的蛋白酶活性,并通过剪切黑色素H3 N-终端尾部的剪切来调节转录

Yonghwan Shin1, Sungmin Kim1, Suhn K Rhie1

  • 1Department of Cancer Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

Cell death and differentiation
|November 25, 2025
PubMed
概括

希斯脱乙酶1 (HDAC1) 具有一种新发现的蛋白酶活性,可以切割希斯H3. 这种活动通过激活致癌基因,对膀癌细胞生长至关重要.

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