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Updated: Jan 10, 2026

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SINE化合物通过异质机制激活出口蛋白1的降解

Casey E Wing1, Ho Yee Joyce Fung1,2, Bert Kwanten3

  • 1Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nature chemical biology
|November 25, 2025
PubMed
概括

核出口选择性抑制剂 (SINEs) 通过异质机制触发癌细胞蛋白出口蛋白1 (XPO1) 的降解. 这一过程涉及ASB8的招募,并利用原生细胞通路,扩大向蛋白质降解策略.

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