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Updated: Jan 10, 2026

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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由MAPK驱动的上皮细胞可塑性驱动着结直肠癌的治疗耐药性

Mark White1,2,3, Megan L Mills1,2, Laura M Millett1,2

  • 1Cancer Research UK Scotland Institute, Glasgow, UK.

Nature
|November 25, 2025
PubMed
概括

在结直肠癌 (CRC) 中的MAPK通路抑制剂可以通过促进干细胞状况引起耐药性. 针对细胞可塑性,特别是在早期或Wnt突变瘤中,可以提高治疗效率.

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