长期COVID:肺部病理生理学及其与认知功能障碍的关系
Keegan R Staab1,2, Marrissa J McIntosh2, Abhilash S Kizhakke Puliyakote2
1Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, US.
长期COVID患者经常经历与肺部问题相关的认知问题. 在129XeMRI上肺气交换受损与这些个体的睡眠,执行功能和大脑 perfusion 差异相关.
科学领域:
- 肺部医学 肺部医学
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 后急性COVID-19 (长期COVID) 呈现持续的身体和认知症状.
- 长期COVID肺部病理生理学和认知功能障碍之间的关系尚不清楚.
研究的目的:
- 研究长期COVID患者肺功能和认知表现之间的联系.
- 为了探索肺气交换,脑成像发现以及认知和睡眠症状之间的相关性.
主要方法:
- 从一个后COVID-19诊所招募了长COVID参与者.
- 使用PROMIS问卷和NIH工具箱认知电池评估认知功能.
- 利用肺功能测试,结构性/功能性脑部MRI和XE MRI进行详细的肺和脑部评估.
主要成果:
- 参与者报告了显著的认知困难,焦虑,抑郁和睡眠障碍.
- 客观认知测试显示,表现通常在正常范围内.
- 减少的XeMRI气体交换与增加的睡眠障碍,较差的执行功能和在脑MRI上更高的脑输液相关.
结论:
- 研究结果表明,在长期COVID中,肺部病理生理学和认知功能障碍之间存在联系.
- 在长期COVID患者中,XeMRI可能会揭示微妙的肺部异常,影响认知和睡眠症状.
- 需要进一步的研究,以阐明长期COVID中呼吸和神经系统连接的机制.
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