相关实验视频

Updated: Jan 6, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

在扩散大B细胞淋巴瘤中通过CXCR4/CXCL12对EZH2调节Treg细胞透的研究

Hongxia Wang^1,2, Dongyu Liang³, Yu Qian¹

¹Departments of Oncology, The First Affiliated Hospital of Soochow University, No. 188, Shizi Street, Suzhou, 215100, China.

Clinical and experimental medicine

|November 25, 2025

概括

增强Zeste同类2 (EZH2) 促进扩散大B细胞淋巴瘤 (DLBCL) 的增长,通过调节C-X-C化学因子受体4型 (CXCR4) 和招募调节性T细胞 (Treg). 这种EZH2/miR-9/CXCR4通路突出显示了DLBCL的潜在免疫治疗点.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

增强Zeste同源2 (EZH2) 是一种在各种瘤中过度表达的甲基转移酶,促进瘤生长和免疫逃避.
C-X-C 化学因子受体4型 (CXCR4) 和它的联体C-X-C 动机化学因子联体12 (CXCL12) 涉及瘤入侵,迁移和免疫细胞透.
在扩散性大B细胞淋巴瘤 (DLBCL) 中EZH2和CXCR4之间的协同关系以及它们在免疫逃逸中的作用仍然不清楚.

研究的目的:

研究DLBCL中EZH2和CXCR4之间的关系.
阐明EZH2影响DLBCL瘤微环境和免疫逃脱的机制.
探索针对DLBCL免疫疗法的EZH2/miR-9/CXCR4通路的潜力.

主要方法:

在DLBCL患者样本中分析EZH2和CXCR4表达.
在体外共培实验中使用人类外周血液单核细胞 (PBMC) 和DLBCL细胞系.
在C-NKG小鼠中使用皮下移植瘤模型的体内研究.

主要成果:

大约90.7%的DLBCL病例表现出中高的EZH2和CXCR4.4表达.
高EZH2和CXCR4表达与增加的CXCL12水平和DLBCL中更高的Treg细胞透相关.
EZH2通过miR-9下调调节对CXCR4进行上调,导致Treg细胞分化和透的增加,促进瘤生长和体内免疫逃逸.

结论:

在DLBCL的发展和进展中,EZH2/miR-9/CXCR4通路至关重要.
高EZH2表达通过CXCR4/CXCL12轴招募Treg细胞进入DLBCL微环境,有助于免疫逃逸.
EZH2及其信号通路代表了DLBCL免疫治疗的有希望的治疗点.

关键词:

扩散大的B细胞淋巴瘤.EZH2;CXCR4 这是一个很好的例子.免疫逃脱是为了逃脱免疫.在Treg细胞中.在 miR-9 系统中,

更多相关视频

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

相关概念视频

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Receptor Downregulation in MVBs

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.