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与HPV相关的多种类型鼻癌的单细胞转录组分析揭示了MYB-HPV关联

Avishai Wizel¹, Matthew D A Spence², Michael Mints³

¹The Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

NPJ precision oncology

|November 25, 2025

概括

人类乳头瘤病毒 (HPV) 相关的鼻癌细胞显示MYB表达增加,与腺状囊性癌不同. 这种HPV-MYB链接可能为HPV驱动的癌症提供新的治疗点.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
病理学病理学病理学

背景情况:

人类乳头瘤病毒 (HPV) 相关的多表型鼻癌 (HMSC) 是一种罕见的瘤.
HMSC类似于腺囊性癌 (ACC),但具有惰的行为.
这两种瘤都显示MYB原基因升调,但HMSC缺乏在ACC中发现的MYB转位.

研究的目的:

调查HPV和MYB在HMSC中的表达之间的关系.
为了比较HMSC的基因表达模式与ACC和口腔状细胞癌 (OPSCC).
在与HPV相关的恶性瘤中识别潜在的预后标志物.

主要方法:

在HMSC瘤上进行了单细胞RNA测序.
表达模式与已发布的ACC和OPSCC数据集进行了比较.
在HPV阳性OPSCC中进行了验证研究.

主要成果:

恶性HMSC细胞与ACC细胞分开聚集.
与非HPVon细胞相比,与HPV相关的基因表达 (HPVon) HMSC细胞的比例更高,表达了MYB及其标.
在HPV阳性OPSCC的HPVon细胞中证实了MYB上调.
来自HPVon HMSC细胞的264基因特征与HPV阳性OPSCC的更差预后相关.

结论:

在HMSC中,HPV和MYB表达之间存在显著的关联.
识别的基因特征可以作为HPV阳性OPSCC的预后标志物.
对HPV-MYB关联和基因特征的进一步研究可能会导致改善HPV相关癌症的治疗策略.

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