Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

1.6K
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
1.6K
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

840
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
840
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.6K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.6K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

3.1K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.1K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.4K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.4K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.7K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Shared and disease-specific human brain vascular signatures in Alzheimer's disease, frontotemporal dementia, and Huntington's disease.

bioRxiv : the preprint server for biology·2026
Same author

A neuro-epithelial unit regulates immunohomeostasis at barrier surfaces.

Mucosal immunology·2026
Same author

AEG-AESPANC-OPGE-SIED-SPG Ibero-Latin American Guidelines on Acute Pancreatitis (iLATAM-AP).

United European gastroenterology journal·2026
Same author

Tumor-Infiltrating Natural Killer Cell Characterization in Pancreatic Ductal Adenocarcinoma.

Cells·2026
Same author

Cardiolipin Induces CXCL9/CXCL10 Expression in Tumor-Infiltrating Lymphocytes.

Cells·2026
Same author

Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2-deficient environments.

The Journal of experimental medicine·2026

相关实验视频

Updated: Jan 10, 2026

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
08:22

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

6.4K

神经皮质VIP-VIPR1相互作用差异控制肠道1型和2型免疫.

Roksana M Pirzgalska1, Beatriz Henriques-Alves1, Bruno Raposo1

  • 1Champalimaud Foundation. Champalimaud Centre for the Unknown. Champalimaud Research, Lisbon, Portugal.

Nature immunology
|November 25, 2025
PubMed
概括

肠道神经元和肠道上皮细胞通过VIP-VIPR1信号协调免疫力. 这种神经上皮相互作用明显地控制了肠道中的1型和2型免疫反应.

更多相关视频

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine
08:00

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Published on: June 24, 2019

8.6K
Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
12:40

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Published on: April 6, 2015

19.3K

相关实验视频

Last Updated: Jan 10, 2026

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
08:22

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

6.4K
Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine
08:00

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Published on: June 24, 2019

8.6K
Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
12:40

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Published on: April 6, 2015

19.3K

科学领域:

  • 神经免疫学 神经免疫学
  • 胃肠病学 胃肠病学
  • 具有天生的免疫力.

背景情况:

  • 神经系统和免疫系统相互作用,保持粘膜屏障的完整性.
  • 肠道神经元通过神经上皮层相互作用协调肠道免疫的作用尚未完全理解.

研究的目的:

  • 为了确定调节肠道1型和2型免疫力的神经上皮相互作用.
  • 阐明肠道上皮细胞中血管活性肠道受体1 (VIPR1) 的功能及其与肠道神经元的相互作用.

主要方法:

  • 肠道VIPergic神经元的化学基因调节.
  • Vipr1.1. 的表皮特异性基因缺失.
  • 免疫细胞种群和细胞因子的分析.
  • 评估宿主对细菌和寄生虫感染的易感性.

主要成果:

  • 肠上皮细胞表达VIPR1,其调节影响了上皮衍生的细胞因子.
  • 皮质内在的Vipr1删除会损害1型免疫力 (降低警示素,皮质内淋巴细胞).
  • 皮质Vipr1缺乏会增强2型免疫力 (增加警示素,细胞,ILC2s).
  • 神经皮质VIP-VIPR1信号的破坏增加了对细菌感染的易感性,但增强了对寄生虫感染的抵抗力.

结论:

  • 涉及VIP和VIPR1的神经上皮相互作用在差异调节肠道1型和2型免疫力方面发挥着关键作用.
  • 这个轴代表了一个新的多组织机制来编程肠道免疫反应.
  • 了解这些相互作用对于开发针对肠道感染的治疗策略至关重要.