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TA-65对端粒长度,功能结果和炎症的影响:系统性审查和元分析
Xiaojuan Su1, Cheng Wang2, Zhixian Gou2
1Department of Pediatrics/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education)/NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Cell biology and toxicology
|November 25, 2025
概括
TA-65激活端粒酶,延长端粒,特别是在老年人中. 然而,它没有改善身体功能或炎症,并显示出轻微的胃肠道副作用,在试验中没有观察到严重的毒性.
科学领域:
- 老年学和细胞衰老研究研究.
- 对衰老的药理干预措施
- 在衰老研究中的生物标志物验证.
背景情况:
- 来自Astragalus membranaceus的TA-65是一种端粒酶激活剂,研究其抗衰老特性.
- 关于TA-65的机械效应和长期安全性概况的综合研究有限.
研究的目的:
- 对TA-65.5的随机对照试验 (RCT) 进行PRISMA指导的元分析.
- 评估TA-65对端粒长度,功能衰老标志物和安全性的影响.
- 综合目前关于TA-65疗效和毒性的证据.
主要方法:
- 使用随机效应模型对8个RCT (n=750) 的元分析.
- 评估白细胞端粒长度 (LTL),脆弱度指标 (SPPB,握力,6MWT) 和炎症标志物 (hs-CRP,IL-6).
- 利用GRADE标准对证据进行分级,并分析了不良事件 (CTCAE v5.0).
主要成果:
- TA-65显著延长了LTL (SMD=0.47),在60岁以上的人群中影响更大.
- 在功能衰老或炎症标志物中没有观察到显著的改善,这表明端粒功能断开.
- 报告了轻微的胃肠道毒性 (12.4%),但在12个月内没有发现严重的不良事件或瘤发生.
结论:
- TA-65证明了端粒延长的有效性,特别是在老年人中,但未能改善功能衰老.
- 短期安全性是有利的,没有确定剂量依赖性毒性或瘤风险.
- 需要进一步的独立试验来评估TA-65的长期毒性和TA-65在综合老化策略中的作用.
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