一个多世纪的人类生活中的有效连接体
Guoshi Li1,2, Khoi Minh Huynh1,2, Kim-Han Thung1,2
1Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Communications biology
|November 25, 2025
概括
这项研究揭示了指导性大脑网络相互作用在整个生命周期中如何成熟. 有效的连接 (EC) 发展的时间比以前想象的要早,突出了关键的早期大脑可塑性.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 网络神经科学 网络神经科学
背景情况:
- 规范性大脑连接体的发展是评估生长和检测疾病的关键.
- 大多数研究使用非定向功能连接,限制了对定向神经相互作用的洞察力.
- 有效连接 (EC) 模拟神经相互作用,提供有针对性的优势.
研究的目的:
- 为了绘制人类大脑有效连接组的寿命发展.
- 为了比较有效连接 (EC) 与功能连接的发展轨迹.
- 阐明在发育中的大脑网络中管理定向因果相互作用的原则.
主要方法:
- 利用了来自生命周期人类结合体项目的高质量的功能性MRI (fMRI) 数据.
- 绘制了整个生命周期的EC图,以分析发育模式.
- 研究了区域和节点EC演变,包括刺激和抑制成分.
主要成果:
- 全球和网络EC表现出反转的U形发育,在9岁左右成熟,比功能连接更早.
- 区域EC强度在早期发展过程中变化更大,这表明了可塑性窗口.
- 节点EC成熟遵循着激发性和抑制性连接的不同的层次序列,受到感觉运动-关联梯度的约束.
结论:
- 揭示了大脑网络发育中的定向因果相互作用的基本原则.
- 建议EC为个性化大脑评估提供更精确的基础.
- 强调了EC在了解早期大脑可塑性和成熟过程中的重要性.
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