评估细胞AI基础模型在病理与人-in-the-loop丰富的脏病理
Junlin Guo1, Siqi Lu1, Can Cui2
1Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Communications medicine
|November 25, 2025
概括
目前的人工智能 (AI) 基础模型需要改善细胞核细分. 人在循环中的方法提高了模型性能,提高了数字病理学工作流程的效率.
科学领域:
- 人工智能在医学中的应用
- 数字病理学数字病理学
- 计算生物学 计算生物学
背景情况:
- 大规模的人工智能 (AI) 基础模型对医疗保健,包括数字病理学,显示出前景.
- 它们对于细胞核细分等特定任务的有效性尚未得到充分证实.
- 这项研究评估了当前的人工智能模型,并为此任务提出了改进方案.
研究的目的:
- 评估核细分的最先进的细胞基础模型的性能.
- 开发和验证一个人-in-the-loop战略,以提高人工智能模型的性能.
- 在现实世界的数字病理学数据中建立AI模型的基准.
主要方法:
- 策划了一个多中心,多疾病,多物种数据集,来自2542个脏整体幻灯片图像.
- 评估了三种基础模型:Cellpose,StarDist和CellViT. 这三种基础模型包括:
- 在数据丰富和微调方面采用了人为循环策略.
主要成果:
- 细胞ViT显示出最高的基线性能 (F1评分为0.78).
- 用丰富数据进行微调改进了所有模型,StarDist获得了最高的F1得分 (0.82).
- 将伪标签与病理学家纠正的硬贴片相结合,始终提高了性能.
结论:
- 细分细胞核需要进一步开发特定器官的人工智能基础模型.
- 拟议的框架提高了AI模型的性能,减少了专家注释.
- 这种方法支持更有效的临床病理学工作流程.
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