在医疗辅助生殖后出生的儿童的神经发育迟缓:全国人口队列研究
Seung-Ah Choe1,2,3, Eunseon Gwak4, Juyoung Lee5
1Department of Preventive Medicine, Korea University College of Medicine, Seoul, Republic of Korea. seungah@korea.ac.kr.
Journal of neurodevelopmental disorders
|November 25, 2025
概括
通过辅助生殖,包括子宫内授精 (IUI) 和体外受精 (IVF) 怀孕的儿童,患神经发育迟缓的风险略高. 建议对这些儿童进行持续监测.
科学领域:
- 生殖医学 生殖医学
- 发育儿科 发育儿科
- 公共卫生 公共卫生
背景情况:
- 通过医疗辅助生殖产生的儿童的神经发育结果需要进一步的人口层面的表征.
- 了解与不同的受孕方法相关的风险对于家长咨询和临床实践至关重要.
研究的目的:
- 为了比较发生率和神经发育迟缓的相对风险,在自发受孕,子宫内授精 (IUI) 和体外受精 (IVF) 后出生的孩子.
主要方法:
- 一项回顾性队列研究利用了韩国国家医疗保险服务数据 (2017-2023年).
- 包括115,839个单胎,满期,非低出生体重的婴儿出生于不育的妇女.
- 倾向性得分与平衡的受孕模式 (自发,IUI,IVF) 相匹配;神经发育延迟使用韩国发育查测试进行评估.
主要成果:
- 5.7%的儿童表现出神经发育迟缓.
- 与自发受精相比,宫内授精 (IUI) 和体外受精 (IVF) 与延迟受精的风险增加有关 (分别为aHR=1.19和aHR=1.09).
- 在体外受精 (IVF) 显示,精细运动延迟的风险低于IUI.
结论:
- 通过IUI或试管婴儿受孕的儿童表现出温和但在统计学上显著的增加了屏幕阳性神经发育延迟.
- 这些发现强调了神经发育监测在辅助生殖技术后出生的儿童的重要性.
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