常规HPV疫苗接种计划应该包括25-29岁的男性吗? 一个系统审查和全球元分析
Siran Wan1,2, Shunhong Zhang3,2, Saidi Hu4,2
1Department of Gynaecology and Obstetrics, Yaan people's Hospital, Yaan, China.
Journal of translational medicine
|November 25, 2025
概括
将人类乳头瘤病毒 (HPV) 疫苗接种范围扩大到25至29岁的男性提供了显著的个人保护和群体免疫益处. 这支持将这个年龄组纳入疫苗接种计划,以减少HPV传播和相关疾病.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 25-29岁的男性是人类乳头瘤病毒 (HPV) 传播的关键.
- 目前的疫苗接种计划往往因为成本和疗效的担忧而排除了这一群体.
研究的目的:
- 综合关于4vHPV疫苗在男性中有效性的证据.
- 评估HPV疫苗接种对25-29岁未接种疫苗的男性群体的影响.
- 支持将HPV疫苗接种扩展到25-29岁的男性.
主要方法:
- 随机对照试验和观察性研究的系统审查和元分析 (2007年1月至2025年2月).
- 在PubMed,Embase和Cochrane图书馆搜索了关于4vHPV疫苗对男性的疗效和对阴道 (AGW) 的群体影响的研究.
- 使用随机效应模型,对HPV感染和AGW发病率的相对风险 (RRs) 进行了汇总.
主要成果:
- 直接4vHPV疫苗接种减少了13-26岁男性的HPV感染 (RR=0.35).
- 对于25-29岁的男性来说,额外推算的益处显示了22.75%的绝对风险降低 (NNT=4).
- 女性接种疫苗覆盖率 (FVC) ≥50%导致25-29岁未接种疫苗的男性中AGW发病率减少37% (RR=0.63),每年保护率显著增加.
结论:
- 将HPV疫苗接种扩展到25-29岁的男性提供了个人和人口的好处.
- 研究结果支持修订年龄限制政策,将这一人口群体纳入疫苗接种计划.
- 这种纳入可以帮助全球努力消除与HPV相关的疾病,特别是在女性覆盖率低于最佳的情况下.
关键词:
年龄因素 年龄因素异生性的发生群体免疫力是一种群体免疫力.人类乳头瘤病毒疫苗疫苗接种计划中的疫苗接种.男人 男人 男人 男人 男人进行元分析分析.乳头瘤病毒感染的病例系统性审查 系统性审查疫苗的有效性 疫苗的有效性更多相关视频
10:26RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
28.0K
13:41Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
12.9K
相关概念视频
Bias in Epidemiological Studies
1.2K
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
1.2K
Infertility in Males
505
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
505
Prevalence and Incidence
1.4K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.4K
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Vaccinations
51.1K
Overview
51.1K
Cancer Vaccines
917
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
917
