Genenames.org: 2026 年的 HGNC 和 PGNC 资源
Ruth L Seal1, Bryony Braschi1, Kristian Gray1
1HUGO Gene Nomenclature Committee, Department of Haematology, University of Cambridge, School of Clinical Medicine, Cambridge CB2 0PT, UK.
Nucleic acids research
|November 25, 2025
概括
HUGO基因命名委员会 (HGNC) 管理人类基因符号,而新的植物基因命名委员会 (PGNC) 现在负责Populus trichocarpa基因的命名.
科学领域:
- 遗传学 是一个遗传学.
- 生物信息学是一种生物信息学.
- 动物学 动物学
背景情况:
- 人类基因命名委员会 (HUGO Gene Nomenclature Committee,简称HGNC) 负责为人类基因赋予标准化符号和名称.
- 在HGNC数据库中,包含了对蛋白质编码基因,伪基因和非编码RNA基因的广泛记录.
- 高基因基因组委员会通过其网站,www.genenames.org.org,向公众提供基因命名系统的访问权限.
研究的目的:
- 审查HGNC项目中最近的更新和发展情况.
- 引入新成立的植物基因命名委员会 (PGNC) 及其职能.
- 详细说明Populus trichocarpa.植物基因命名的范围和可访问性.
主要方法:
- 策划和批准独特的基因符号和人类基因的描述性名称.
- 开发和维护HGNC数据库,提供全面的基因信息.
- 建立了PGNC及其专门的网站,plant.genenames.org,用于植物基因命名.
主要成果:
- 目前,HGNC数据库拥有超过44400个已批准的基因符号.
- 已经建立了PGNC,并且正在积极批准Populus trichocarpa的基因命名.
- 通过各自的网站,HGNC和PGNC分类公开可访问.
结论:
- 现在,HGNC仍然是人类基因命名的重要资源.
- 建立PGNC标志着在标准化植物基因命名公约方面迈出的重要一步.
- 这些倡议确保在跨物种的遗传研究中进行明确和一致的沟通.
相关概念视频
Next-generation Sequencing
97.6K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
97.6K
Multi-species Conserved Sequences
4.6K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.6K
Genomics
39.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.6K
Single Nucleotide Polymorphisms-SNPs
17.9K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.9K
Genome Annotation and Assembly
20.5K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
20.5K
Nucleic Acids and Nucleotides
13.8K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria....
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria....
13.8K


