针对性阿司匹林给药的效果,基于第一季度结合查预先怀孕不全在早产:一个中断的时间序列分析
Monica Minopoli1, Alicia Martínez-Varea2, Claire Pegorie1
1Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.
BJOG : an international journal of obstetrics and gynaecology
|November 25, 2025
概括
一个阿司匹林干预计划并没有显著降低高风险怀孕中早产 (PTB) 率. 虽然一些结果有所改善,但需要进一步的干预措施来大幅减少PTB.
科学领域:
- 孕产妇与胎儿的医学
- 产科 产科 产科 产科 产科
- 公共卫生 公共卫生
背景情况:
- 第一个三个月的查可以确定高风险的怀孕为早产前和早产 (PTB).
- 阿司匹林预防用于减轻这些高风险怀孕的风险.
研究的目的:
- 评估阿司匹林干预计划对PTB率的影响.
- 评估该计划对高风险妇女的自发早产 (sPTB) 和阳性早产 (iPTB) 的影响.
主要方法:
- 以ARIMA模型使用中断时间序列分析 (ITSA) 进行回顾性研究.
- 在圣乔治大学医院2016年至2022年间对31534例怀孕的分析.
- 从怀孕的第一季度开始,对女性的纳入得到了关注.
主要成果:
- 没有发现阿司匹林干预计划对整体PTB发病率产生显著影响.
- 总PTB和阳性性PTB (iPTB) 的非显著下降趋势被观察到.
- 在早期PTB (<34周) 中也发现了类似的趋势.
结论:
- 第一个三个月的查有效地识别出患PTB高风险的女性.
- 阿司匹林预防和连续评估并没有显著降低自发性或阳性PTB率.
- 需要额外的干预措施,以大大减少高风险人群中的PTB.
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