参与者推的"研究伙伴"能否增加在研究中使用毒品的农村人群的保留率? 一个多站点的随机化试验
April M Young1,2, Kathryn E Lancaster3, Miriam R Elman4
1Department of Epidemiology and Environmental Health, University of Kentucky, Lexington, KY, USA.
Addiction (Abingdon, England)
|November 25, 2025
概括
在纵向研究中,研究伙伴干预并没有改善农村人口使用药物的保留率. 标准的保留策略与研究伙伴方法一样有效.
科学领域:
- 公共卫生 公共卫生
- 成研究 研究成研究
- 临床试验 临床试验
背景情况:
- 保持参与者在纵向研究中,特别是农村人口使用毒品,是具有挑战性的.
- 有效的保留策略对于弱势群体研究结果的有效性至关重要.
- 这项PROUD-R2研究旨在解决农村药物使用者队列中的保留障碍.
研究的目的:
- 与标准保留方法相比,评估"研究伙伴"干预的有效性.
- 在纵向研究中,确定同行支持的方法是否可以提高农村使用毒品的人群 (PWUD) 的保留率.
- 评估一种新的留住策略对参与者随访率的影响.
主要方法:
- 在俄俄州,俄勒冈州和肯塔基州的农村地区进行了一项多站点,双臂随机对照试验.
- 参与者 (n=739) 是18岁以上的PWUD,参加了PROUD-R2研究.
- 干预组获得标准保留加上"研究伙伴"鼓励,而对照组仅获得标准保留.
主要成果:
- 整体保留率为6个月后的50.3%和12个月后的46.1%.
- 只有23.5%的干预参与者成功招募了研究伙伴.
- 对治疗意图的分析显示,研究伙伴干预和6个月或12个月的标准保留之间没有统计学上显著的保留差异.
结论:
- "研究伙伴"干预措施并没有显著改善该农村PWUD队列中的参与者保留率.
- 标准的保留策略似乎与同行招募的"研究伙伴"方法同样有效.
- 可能需要进一步的研究来探索替代或修改的同行支持策略,以改善纵向研究保留率.
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