术前焦虑和抑郁症状 基于性别差异的分层影响口腔状细胞癌的结果
Lirui Zhang1, Chang Liu2, Qiaoshi Xu1
1Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
Head & neck
|November 25, 2025
概括
手术前的焦虑和抑郁症状显著影响口腔癌的生存率和治疗时间. 这些心理困扰因素对男性和女性的结果有不同的影响,突显了需要性别特定护理的需要.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 口腔状细胞癌 (OSCC) 带来了重大的健康挑战.
- 手术前的心理困扰,包括焦虑症状 (AS) 和抑郁症状 (DS),可能会影响OSCC患者的结果.
- 了解这些影响对于优化患者护理和治疗策略至关重要.
研究的目的:
- 调查OSCC患者手术前焦虑和抑郁症状以及临床结果之间的关联.
- 检查这些心理因素对治疗开始时间 (TTI) 的影响.
- 探索这些协会中潜在的性别差异.
主要方法:
- 分析了725名OSCC患者的队列.
- 卡普兰-梅尔和考克斯的比例危险模型被用来评估生存率.
- 使用加速失效时间模型来估计TTI.
主要成果:
- 女人表现出更高的AS和DS的流行率和严重程度.
- 在女性中,轻度的AS和DS与增加的死亡风险有关.
- 轻度DS在女性中延长了TTI,而轻度DS或中度至重度AS在男性中减少了TTI.
结论:
- 手术前的心理困扰,特别是焦虑和抑郁,根据性别对OSCC患者的生存率和TTI产生不同的影响.
- 这些发现强调了在OSCC管理中考虑心理因素的重要性.
- 特定于性别的方法可能是必要的,以解决OSCC患者的心理需求.
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