与唐氏综合征儿童阻塞性睡眠呼吸暂停相关的同时出现的疾病和睡眠症状
Taylor A Curry1, Emily Cooper2, John Brinton2,3
1Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Pediatric pulmonology
|November 25, 2025
概括
睡眠呼吸障碍 (SDB) 在患有唐氏综合征 (DS) 的儿童中很常见. 目击性呼吸暂停和更高的BMI与这个人群中更严重的阻塞性睡眠暂停 (OSA) 有关.
科学领域:
- 儿科肺病学 儿科肺病学
- 睡眠医学 睡眠医学
- 遗传学 遗传学 是一个
背景情况:
- 睡眠呼吸障碍 (SDB) 在患有唐氏综合征 (DS) 的儿童中非常普遍.
- 美国儿科学会建议在3至4岁的儿童中进行常规的多睡眠检查.
- 了解DS中的SDB模式对于早期干预至关重要.
研究的目的:
- 通过使用多眠图数据,对患有DS的儿童的临床症状和呼吸模式进行表征.
- 在这个队列中确定与阻塞性睡眠呼吸暂停 (OSA) 严重程度相关的因素.
主要方法:
- 在中等海拔地区对526名DS儿童的多睡眠图数据进行了回顾性分析.
- 主要结局:阻塞性呼吸暂停下指数 (OAHI).
- 二次结果:中央呼吸暂停指数 (CAI),气体交换,睡眠症状和并发症;与OSA严重程度的相关性进行了探索.
主要成果:
- 79.7%的DS儿童被诊断患有OSA (OAHI≥2次/小时);51.0%的儿童患有中度/重度OSA.
- 目击者呼吸暂停与中度/重度OSA正相关.
- 更高的BMI类别与更严重的OSA显著相关 (p=0.02).
- 不安静的睡眠和食困难与OSA严重程度有负面关联.
结论:
- 在患有唐氏综合征的儿童中,OSA的高患病率得到证实.
- 护理人员报告的目击性呼吸暂停事件和BMI类别与增加的OSA严重程度有关.
- 这些发现强调了监测DSB在患有DS的儿童中的重要性.
相关概念视频
Sleep Apnea
456
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
456
Oppositional Defiant Disorder
591
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Diagnostic Criteria and...
591
Other Pulmonary Disorders
1.5K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.5K
Nightmares and Night Terrors
425
Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares...
Nightmares...
425
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.5K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.5K
Narcolepsy
470
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
470


