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最初循环的CD138预测了微观多炎患者的末期病
Jung Yoon Pyo1, Yong-Beom Park2,3, Sang-Won Lee2,4
1Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Yonsei medical journal
|November 25, 2025
概括
诊断时循环中的CD138水平可以预测微观多炎 (MPA) 患者的末期病 (ESKD) 进展. 较高的CD138水平表明风险增加和生存率降低,有助于早期干预策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 临床生物标志物 临床生物标志物
背景情况:
- CD138是一种细胞表面蛋白质甘氨酸,对血细胞的存活和粘附至关重要.
- 循环中的CD138可以通过ectodomain shedding在血清中检测到.
- 微观多炎 (MPA) 是一种自身免疫性疾病,可能导致损伤.
研究的目的:
- 评估血清CD138水平在诊断时对预测MPA患者末期病 (ESKD) 进展的临床有用性.
- 确定循环中的CD138是否可以作为MPA的预后生物标志物.
主要方法:
- 招募了65名新诊断的MPA患者.
- 收集的数据包括血管炎活动指数,临床和实验室参数.
- 从基线血清中测量了循环中的CD138水平,并通过ROC分析确定了预测切线.
主要成果:
- 中位数CD138水平为62.8 ng/mL,与疾病活性呈正相关,与专蛋白呈负相关.
- 18.5%的患者进展到ESKD.
- 患有CD138≥73.3 ng/mL的患者患有ESKD进展的风险增加了10.588倍,ESKD无存活率显著降低 (p=0.002).
结论:
- 诊断时循环中的CD138是一种临床上有用的生物标志物,用于预测MPA中ESKD进展.
- 测量CD138水平可以帮助识别高风险的MPA患者.
- 这种生物标志物可以指导及时的治疗干预措施,以改善患者的治疗结果.
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