在COVID-19期间优先考虑脏移植:单一中心的经验和未来激增计划的教训
Abishek Balakrishnan1,2, Keir Mehta1, Aydin Caglayan3
1School of Medicine, Cardiff University, Cardiff, GBR.
Cureus
|November 25, 2025
概括
医学上必要,时间敏感 (MeNTS) 评分有助于在COVID-19大流行期间优先考虑移植患者,显示与成功移植和良好结果相关的较低得分.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植手术 移植手术
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,COVID-19大流行严重扰乱了选择性外科服务.
- 优先级框架,如医疗必要,时间敏感 (MeNTS) 评分,被采用来管理必要的手术.
- 早期关于脏移植的流行病数据对于了解长期影响至关重要.
研究的目的:
- 评估卡迪夫移植单位在COVID-19流行病的第一年使用MeNTS得分的病例选择过程.
- 评估移植接受者和被暂停手术的患者的早期结果.
- 分析MeNTS得分在流行病条件下优先考虑患者的有效性.
主要方法:
- 2020年3月1日至2021年3月1日期间,成年移植候选人的单中心,回顾性队列研究.
- 对于移植 (n=62) 和暂停 (n=45) 患者的MeNTS分数的回顾性计算.
- 主要结局包括移植功能,患者存活率 (90天和一年),以及COVID-19感染率和严重程度.
主要成果:
- 与暂停患者 (61) 相比,移植患者 (58) 的MeNTS中位数较低 (p < 0.001).
- 两组患者的一年生存率都很高 (96.7%的移植 vs 97.8%的暂停).
- 32%的移植患者出现了延迟的移植功能,移植失败率为8.1%;13%的患者感染了COVID-19.
结论:
- 卡迪夫移植部门在最初的流行病年成功优先考虑了MeNTS得分较低的患者.
- 尽管存在与流行病有关的挑战,但观察到可接受的短期患者和移植结果.
- 该MeNTS评分提供了一个透明的选框架,但建议对未来的危机进行移植特定的调整和前性验证.
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