在血清阳性类风湿性关节炎中提升ITGAV表达:诊断潜力和免疫病理见解
Yu Shan1,2,3, Jianan Zhao1,2,3, Yunshen Li1,2,3
1Department of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Journal of inflammation research
|November 25, 2025
概括
综合素αV (ITGAV) 在类风湿性关节炎 (RA) 患者中升高,显示出作为诊断生物标志物的潜力. 这一发现有助于早期发现RA并了解疾病机制.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 生物标志物发现发现
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,导致关节炎症和破坏.
- 目前的RA诊断方法缺乏足够的灵敏度,无法及早发现.
- 对于早期RA诊断和分层而言,迫切需要可靠的生物标志物.
研究的目的:
- 研究整合素αV (ITGAV) 作为类风湿性关节炎的潜在诊断生物标志物.
- 评估ITGAV表达与RA患者临床和血清学参数的相关性.
- 使用接收器操作特征 (ROC) 曲线分析来探索ITGAV的诊断性能.
主要方法:
- 使用ELISA对RA患者,骨关节炎患者和健康对照患者的外周血液样本中ITGAV表达的量化.
- 对ITGAV水平与临床参数 (血清学标记,超声波得分,疾病活性指数) 的相关性分析.
- 对转录组和单细胞RNA测序数据的分析,以确定免疫细胞子集中的ITGAV表达;用于诊断准确性的ROC曲线分析.
主要成果:
- 在RA患者中,ITGAV水平显著更高,特别是那些对类风湿因子 (RF) 和抗周期性 (anti-CCP) 抗体血清阳性的患者.
- 它的ITGAV表达与RF和反CCP位数正相关.
- 单细胞分析显示ITGAV在促炎性巨细胞和T细胞中的丰富,与突细胞厚度有正相关性;ROC分析表明诊断精度高 (AUC>0.96).
结论:
- 综合素αV (ITGAV) 在血清阳性RA中被上调,显示出作为诊断和分层的非侵入性生物标志物的潜力.
- ITGAV在炎症性免疫细胞中的表达和与突炎的关联表明它在RA病变发生过程中的作用.
- 需要进一步的研究来验证ITGAV在个性化RA管理中的实用性.
相关概念视频
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
460
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
460
Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K
The JAK-STAT Signaling Pathway
11.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
11.8K
T Cell Types and Functions
2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
Autoimmune Disorders
1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.4K
Rheumatic Heart Disease I: Introduction
415
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
415


