与喘患者全身皮质类固醇使用相关的因素:现实生活研究
Gregorio Alvarez-Vera1, Lourdes Avila2, Elsy M Navarrete-Rodriguez2
1Allergy and Immunology, IMSS Hospital General de Zona No. 30, Iztacalco, Mexico City, MEX.
Cureus
|November 25, 2025
概括
在墨西哥喘患者中,系统性皮质类固醇 (SCS) 的过度使用与严重的疾病,eosinophilic炎症和鼻多重症有关. 减少对SCS的依赖对于尽量减少不良影响和改善喘管理至关重要.
科学领域:
- 肺部病理学 肺部病理学
- 临床医学 临床医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 喘是一种具有重大全球影响的慢性呼吸道疾病.
- 系统性皮质类固醇 (SCS) 用于严重的喘,但具有风险.
- 关于墨西哥喘患者的SCS使用模式的数据有限.
研究的目的:
- 确定与墨西哥喘患者系统性皮质类固醇 (SCS) 使用相关的因素.
- 调查SCS使用与喘严重程度,内型,并发症和诊断持续时间之间的关系.
- 为减少SCS过度使用和相关不良事件的策略提供信息.
主要方法:
- 一项涉及墨西哥152名喘患者的多中心两视研究.
- 数据收集包括关于SCS使用,喘特征和并发症的临床和实验室信息.
- 统计分析采用了描述和推断方法.
主要成果:
- 近一半 (48.7%) 的患者在过去12个月中使用SCS.
- 在严重喘 (81.8%),eosinophilic内型 (83.3%) 和鼻多重症患者 (100%) 中,SCS的使用显着更高.
- 在SCS使用者中观察到更高的中等乙酸细胞数量 (208对114).
结论:
- 疾病的严重程度,eosinophilic炎症和鼻多重症是与喘中SCS使用相关的关键因素.
- 这些发现强调了针对性治疗的必要性,如生物药物,以减少SCS依赖.
- 优化早期诊断和喘管理对于更好的结果和减少长期风险至关重要.
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