血液造血干细胞移植后儿童的通风异质性和肺组织异常
Paulius Kalibatas1, Rūta Bleifertaitė1, Ramunė Vaišnorė2
1Faculty of Medicine, Clinic of Children Diseases, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
概括
造血干细胞移植 (HSCT) 可以在儿童中引起亚临床肺损伤. 多重呼吸洗 (NMBW) 检测到通风异质性,药物效应因调节剂而异.
科学领域:
- 儿科肺病学 儿科肺病学
- 血液学 血液学 血液学
- 移植医学 移植医学
背景情况:
- 造血干细胞移植 (HSCT) 对于治疗儿科血液学疾病至关重要.
- 在HSCT后的长期肺部健康需要仔细监测.
- 在HSCT后评估通风异常对于患者的治疗结果至关重要.
研究的目的:
- 为了评估小儿HSCT幸存者的肺部异常,使用多重呼吸洗 (NMBW) 和肺部超声波.
- 确定调节和移植对宿主病 (GVHD) 预防药物对通风异质性的影响.
- 在HSCT后的儿童中识别亚临床肺损伤.
主要方法:
- 儿科HSCT接受者的横截面研究 (自身和异质).
- 使用多次呼吸洗 (NMBW) 来评估通风异质性.
- 使用肺超声波来检测肺部异常.
- 分析了特定调节药物和通风异质性之间的关联.
主要成果:
- 异常的肺清除指数 (LCI) 在4/9个自身和16/23个异性HSCT患者中发现.
- 布苏尔与HSCT后的较低导电通风异质性 (第二) 相关.
- 弗鲁达拉宾和三硫与更高的Scond值有关.
- 肺部超声波显示出有限的整合.
结论:
- 在小儿HSCT幸存者中,NMBW有效检测亚临床肺损伤.
- 通风异质性受到调节药物的影响:高于fludarabine/treosulfan,低于busulfan.
- 肺部超声波检查结果与调节药物没有很强的联系.
更多相关视频
06:15Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
Published on: November 10, 2023
1.4K
09:54Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
2.2K
相关概念视频
01:19Factors Affecting Pulmonary Ventilation
2.7K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
2.7K
01:22Bone Marrow Sampling and Transplants
801
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
801