系统性炎症反应指数 (SIRI) 与孕妇膀过活之间的关联:基于NHANES数据库的横截面研究
Jia Huang1,2, Lu Zhao3, Hanchi Zhang4
1Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
概括
系统性炎症响应指数 (SIRI) 的升高与孕妇的过度活性膀 (OAB) 风险较高有关. 这一发现可能有助于早期识别高风险个体.
科学领域:
- 生殖健康 生殖健康
- 炎症生物标志物 炎症生物标志物
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 怀孕涉及独特的生理变化,这可能会增加过度活性膀 (OAB) 的风险.
- 系统性炎症反应指数 (SIRI) 是系统性炎症的新标志物.
- 在孕妇中SIRI和OAB之间的关联仍然不清楚.
研究的目的:
- 调查SIRI和OAB发生和严重程度在孕妇之间的关系.
- 探索SIRI作为该群体OAB风险早期指标的潜力.
主要方法:
- 在NHANES (2005-2018) 中分析了402名孕妇的数据.
- 利用加权后勤和线性回归模型来评估SIRI与OAB和OAB症状评分 (OABSS) 的关联.
- 采用受限立方线模型来检查潜在的非线性关系.
主要成果:
- 在孕妇中,SIRI升高和OAB风险增加之间发现了显著的正相关性.
- SIRI显示与过度活跃膀症状评分 (OABSS) 有显著的积极关联.
- 亚组分析证实了不同的人口结构层的一致趋势.
结论:
- 在孕妇中,SIRI与OAB风险和症状严重程度正相关.
- 升高的SIRI可以作为临床医生有价值的早期识别工具,以检测高风险的OAB孕妇.
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