墨西哥儿科人口中与代谢功能障碍相关的脂肪性肝病的心血管风险
Brian González-Pérez1,2, Ricardo Salas-Flores3,4, Raúl De León-Escobedo3
1Department of Family Medicine, Family Medicine Unit No. 38 of the Mexican Institute of Social Security, Tampico, Mexico.
儿童代谢功能障碍相关的脂肪性肝病 (MASLD) 与早期动脉样硬化和心血管风险有关. 早期检测和多因素方法对于治疗儿科患者这种疾病至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 心血管健康 心血管健康
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 在儿童中越来越普遍.
- MASLD与代谢综合征和胰岛素抵抗有关.
- 在儿科MASLD中早期识别心血管风险至关重要.
研究的目的:
- 检查MASLD与儿童心血管风险之间的关联.
- 评估人类,代谢和肝脏标志物对儿科MASLD心血管风险的预测价值.
- 在患有MASLD的儿童中,使用心动脉内膜介质厚度 (CIMT) 评估亚临床动脉样硬化.
主要方法:
- 一项涉及5-18岁儿童超重/肥胖和疑似肝硬化症的横截面研究.
- 通过超声波诊断MASLD;通过CIMT和代谢标志物评估心血管风险.
- 用多个回归模型来确定心血管风险的预测因素.
主要成果:
- 与对照组相比,患有MASLD的儿童的BMI百分位数,静脉血压和HOMA-IR显著更高.
- MASLD患者的CIMT增加,表明早期的血管改造.
- 包括CIMT,代谢和肝脏标志物的预测模型显示出高预测值 (R2 = 0.935).
结论:
- MASLD与子临床动脉样硬化和儿童心脏代谢失调有很强的关联.
- 在儿科MASLD中,多因素方法对心血管风险评估至关重要.
- 在患有MASLD的儿童中,可以检测到早期的心血管变化,因此需要早期风险分层.
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