在纤维肌痛的内分泌并发症
Eli Magen1,2,3, Lior Tolkin3,4, Suhail Aamar3,5
1Leumit Health Services, Tel Aviv - Jaffa, Tel Aviv, Israel.
与对照人群相比,纤维肌痛 (FM) 患者表现出更高的内分泌疾病,包括甲状腺疾病和糖尿病的患病率. 这些发现表明FM和荷尔蒙失衡之间存在共同的潜在机制.
科学领域:
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
- 慢性疼痛综合征 慢性疼痛综合征
背景情况:
- 纤维肌痛 (FM) 是一种复杂的慢性疼痛疾病.
- 新出现的证据将FM与免疫和内分泌系统功能障碍联系起来.
研究的目的:
- 为了确定 FM 患者内分泌伴随性疾病的患病率.
- 为了比较 FM 患者的内分泌疾病率与匹配的对照人群.
主要方法:
- 一个基于人口的病例控制研究,利用一个大型的医疗保健数据库.
- 9,232名成年 FM 患者 (ACR 标准) 与 46,160 名对照进行了匹配.
- 通过ICD-9代码识别的内分泌疾病;用于分析的多变量逻辑回归.
主要成果:
- FM患者的甲状腺疾病 (哈西莫托,格雷夫斯),糖尿病 (1型和2型),骨质疏松症和维生素D缺乏症的发生率显著更高.
- 在 FM 患者中观察到库辛综合征和益生菌瘤的几率增加.
- 虽然一些不太常见的内分泌条件在FM中更频繁,但意义不同.
结论:
- 这项研究揭示了纤维肌痛与广泛的内分泌并发症之间存在显著的关联.
- 建议在FM和内分泌疾病之间存在共享的病理生理机制.
- 需要进一步的研究来探索因果关系和内分泌查在FM的潜在益处.
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