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控制良好的糖尿病中隐藏的膀功能障碍:对患有下尿路症状的男性进行尿动力学研究
Yoshihisa Matsukawa1, Shun Takai1, Tsuyoshi Majima1
1Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Lower urinary tract symptoms
|November 25, 2025
概括
得到良好控制的糖尿病 (DM) 可以损害膀功能,并增加男性下泌尿道症状 (LUTS). 在这些患者中,更长的DM持续时间和更小的前列腺大小与dtrusor低活性 (DU) 有关.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 糖尿病是一种全身性疾病,具有潜在的并发症.
- 在没有明显并发症的情况下得到良好控制的DM对下游泌尿道症状 (LUTS) 的影响需要详细的研究.
- 了解这些影响对于糖尿病患者的LUTS管理至关重要.
研究的目的:
- 对于没有神经病变,视网膜病变或肺部病变的男性,研究受良好控制的糖尿病 (DM) 对下游泌尿道症状 (LUTS) 和膀功能的影响.
- 为了比较患有良好控制的DM的男性与非糖尿病对照组之间的泌尿动力学参数.
- 在患有DM的男性中确定与膀功能障碍相关的临床因素.
主要方法:
- 包括从未接受过治疗的LUTS男性,将他们分为一个DM组 (HbA1c <7.0%,没有并发症) 和一个匹配的非DM对照组.
- 两个组之间的泌尿动力学参数的比较,包括膀空气效率,最大流量和膀收缩指数.
- 检查临床因素,如DM持续时间和前列腺大小,与DM组内体低活性 (DU) 相关.
主要成果:
- 与对照组相比,患有良好控制的DM男性的膀空气效率,最大流量和膀收缩指数显著降低.
- 在DM组中,除体低活性 (DU) 的患病率明显高 (41.7%),高于非DM组 (25.9%).
- 在DM组中,更长的DM持续时间和更小的前列腺体积被确定为开发DU的显著风险因素.
结论:
- 得到良好控制的糖尿病有负面影响于胞收缩性和膀功能,导致LUTS.
- 患有LUTS和得到良好控制的DM的男性,特别是患病持续时间较长和前列腺较小的男性,患膀功能障碍的风险增加.
- 这些发现强调了在患有LUTS的糖尿病患者中评估膀功能的重要性,即使血糖控制良好.
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