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Updated: Jan 10, 2026

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在暴露-反应分析中解决因果关系和同质性假设

Mats O Karlsson1, Divya Brundavanam1

  • 1Department of Pharmacy, Uppsala University, Uppsala, Sweden.

Clinical pharmacology and therapeutics
|November 25, 2025
PubMed
概括

新的仪器变量 (IV) 模型通过评估因果关系和同质性来改善药理动力学分析 (PKPD). 分区效应 (PE) 模型准确地估计了各种混场景中的药物效应,与标准PKPD模型不同.

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Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
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