体重不足和2型糖尿病的心血管风险:一项韩国全国性的研究
Ji-Hong Park1, Kyungdo Han2, Hun Jee Choe3
1Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
European heart journal
|November 25, 2025
概括
体重不足的2型糖尿病 (T2DM) 患者面临更高的心血管疾病 (CVD) 风险,特别是严重体重不足的患者. 这凸显了对体重不足的T2DM患者需要专门的管理策略,以减少心血管疾病事件.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 瘦身2型糖尿病 (T2DM) 越来越普遍.
- 关于T2DM中分层低体重类别和心血管疾病 (CVD) 风险的研究有限.
- 在T2DM患者中,体重不足的状况需要进一步调查其对心血管疾病风险的影响.
研究的目的:
- 调查T2DM患者体重不足和心血管疾病风险之间的关联.
- 检查体重不足严重程度对心血管疾病风险的影响.
- 为了比较T2DM中不同体质指数 (BMI) 类别的CVD风险.
主要方法:
- 全国范围的队列研究使用韩国国家医疗保险服务数据库 (2,064,406名T2DM成年人).
- 按BMI进行分类:体重不足 (轻度,中度,严重),正常体重,超重和肥胖.
- 用于评估心血管疾病结果 (心肌梗塞,缺血性中风) 的Cox比例危险模型,经过调整以考虑混因素.
主要成果:
- 所有体重不足组的CVD风险明显高于正常体重的个体.
- 严重体重不足 (BMI <16 kg/m2) 显示最高心血管疾病风险 (aHR 1.49),超过与肥胖相关的风险 (BMI ≥35 kg/m2).
- 观察到BMI和心血管疾病风险之间的反向J形关联,体重不足和肥胖极端都增加了风险.
结论:
- 体重不足状态,特别是严重体重不足,是T2DM患者心血管疾病的重要危险因素.
- 严重体重不足的T2DM患者的心血管疾病风险超过肥胖T2DM患者的风险.
- 需要专门的临床指导方针来管理体重不足的T2DM患者,以有效地减轻心血管风险.
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