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再生纤维素水凝用于绿色,高效和选择性的肝素提取

Zhuojun Meng¹, Pengfei Zhang¹, Ke An¹

¹Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China.

Biomacromolecules

|November 25, 2025

概括

研究人员开发了一种绿色纤维素水凝,用于高效的肝素提取,为基于塑料的吸附剂提供可持续的替代品. 这种新型材料具有很高的选择性和可重复使用性,解决了抗凝固剂净化方面的挑战.

科学领域:

生物材料科学生物材料科学
化学工程是化学工程的重要组成部分.
生物技术是生物技术.

背景情况:

氨酸净化具有挑战性,目前的方法使用基于石油的吸附剂,这些吸附剂存在微塑料风险.
需要可持续和安全的替代方法来恢复抗凝固剂.

研究的目的:

开发一种基于纤维素的绿色水凝,用于选择性和高效的肝素提取.
与商业吸附剂相比,评估新型水凝的性能.

主要方法:

用四级基对纤维素纳米纤维素 (PCCNFs) 的修改.
离子液体 (IL) 溶解和再生以形成阴阳性纤维素 (cCell) 水凝.
电子喷雾制造单分散球体用于基于柱子的操作.

主要成果:

基于PCCNF的水凝在1分钟内捕获了~88%的肝素,超过了商业Amberlite IRA-900.
再生cCell水凝显示出对黑巴林的高选择性,而不是蛋白质污染物.
水凝在多个提取周期中表现出极好的可重复使用性.

结论:

基于再生纤维素的水凝是有效的,可持续的替代品塑料吸附剂的氨酸回收.
这项技术为净化肝素和其他多电解质提供了可扩展的解决方案.
开发的水凝减轻了与微塑料污染相关的潜在健康风险.

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