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构建植物 lncRNAs 的表观遗传调节景观 - - 一项利用新型专业平台 PERlncDBDB 的探索

Yan Li^1,2, Wenjing Yang¹, Jiazhi Liu^2,3

¹CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Yunnan Key Laboratory of Crop Wild Relatives Omics, State Key Laboratory of Plant Diversity and Specialty Crops, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, 650223, China.

The Plant journal : for cell and molecular biology

|November 25, 2025

概括

长非编码RNAs (lncRNAs) 在植物发育和压力中起着至关重要的作用. 这项研究揭示了19种植物物种中lncRNAs的独特表观遗传调节,突出了DNA甲基化和基因素修饰.

科学领域:

植物分子生物学植物分子生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
基因组学就是基因组学.

背景情况:

长非编码RNAs (lncRNAs) 越来越多地被认为是植物生物学中的角色.
lncRNAs的表观遗传调节是一个不断增长的研究领域,但在植物中仍未得到充分研究.
关于各种植物物种中 lncRNAs 的表观基因组景观的数据有限.

研究的目的:

在多种植物物种中全面分析 lncRNA loci 的表观遗传学模式.
为了确定特定的表观遗传标记和规范 lncRNA 表达的调节机制.
开发一个资源来探索植物 lncRNA表观遗传学.

主要方法:

综合分析了来自 19 种植物的 16 万多个 lncRNA.
使用了6715个ChIP-seq,BS-seq和RNA-seq数据集.
开发了用于数据可视化和分析的PERlncDB平台.

主要成果:

在lncRNA区域观察到DNA甲基化升高,特别是在可转移元素相关的lncRNA中.
在lncRNA位点的组织特异性激活质子修饰,与蛋白质编码基因不同.
通过特定的表观遗传因素和跨物种保留的调节机制确定了lncRNA位点的选择性调节.

结论:

与蛋白质编码基因相比,植物 lncRNAs 呈现出独特的表观遗传调节模式.
控制lncRNAs的表观遗传机制在植物物种中得到保护,这表明功能稳定性.
PERlncDB平台为未来对植物 lncRNA表观遗传学的研究提供了宝贵的资源.

关键词:

通过DNA甲基化.在 LncRNAs 中.显基因组是一个表观基因组.基斯顿基因基因基因基因基因基因基因基因基因基因基因基因基因欧米克斯数据库数据库的数据库.植物植物植物植物植物.

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相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...