CXCL13作为复杂常见变量免疫缺陷的生物标志物
Ioasaf Karafotias1, Helene Martini1, Charlotte V Lee1
1Department of Immunological Medicine, King's College London, King's Health Partners, King's College Hospital NHS Foundation Trust, School of Immunology and Microbial Sciences, Denmark Hill, London, SE5 9RS, UK.
Journal of clinical immunology
|November 25, 2025
概括
在常见变性免疫缺陷 (CVID) 中,血清CXCL13水平升高,特别是在女性中. 更高的CXCL13表明更多的临床并发症和特定的B细胞变化,这表明它是复杂的CVID疾病的生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 常见变性免疫缺陷 (CVID) 的特点是抗体产生受损和反复感染.
- 目前对CVID的预后生物标志物是有限的.
- 胚芽中心反应和T卵泡辅助细胞 (Tfh) 的调节器CXCL13,涉及B细胞活动,在炎症条件下升高.
研究的目的:
- 在CVID患者中调查血清CXCL13水平的变化.
- 为了确定血清CXCL13是否可以根据临床和免疫表型分层CVID患者.
主要方法:
- 在CVID患者和健康捐赠者 (HD) 之间比较血清CXCL13水平.
- 在CVID中,CXCL13水平与临床并发症和免疫细胞表型的关联.
主要成果:
- 血清CXCL13水平在CVID患者中明显高于HD患者,尤其是女性.
- 增加的CXCL13与CVID中的临床并发症和循环Tfh细胞 (cTfh) 有积极的相关性.
- 更高的CXCL13水平与增加的临床并发症,CD21低 B细胞或减少切换记忆B细胞有关.
结论:
- CXCL13作为一个有价值的生物标志物用于分类异质CVID患者.
- 血清CXCL13可以帮助在CVID中识别复杂疾病表型.
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