相关实验视频

Updated: Jan 10, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

在成年人中,GH替代疗法刺激纤维细胞激活蛋白-α活性

Amanda Bæk^1,2,3, Anne Kathrine Nissen Pedersen^2,3, Tine Borum Billeskov^1,2,3

¹Department of Endocrinology and Internal Medicine, Department of Clinical Medicine, Aarhus University, Aarhus 8200, Denmark.

European journal of endocrinology

|November 25, 2025

概括

增长激素 (GH) 替代疗法增加了纤维细胞激活蛋白-α (FAPα) 的活性和水平,增长激素缺乏的成年人. 这表明FAPα是GH活性的生物标志物,可能导致GH诱导的纤维化.

科学领域:

内分泌学在内分泌学.
生物化学生物化学
纤维化研究纤维化研究

背景情况:

增长激素 (GH) 影响原的循环,在儿童中具有合成代谢作用,在成人中可能促进纤维化.
纤维细胞激活蛋白-α (FAPα) 是一种蛋白蛋白酶,向原和FGF21,具有高水平的活跃巨变.

研究的目的:

量化成人生长激素缺乏症 (GHD) 患者的循环FAPα活性和水平.
评估GH替代疗法后FAPα基质的变化,包括原循环生物标志物和FGF21.

主要方法:

在GH治疗3-6个月前和之后,从GHD患者的血清样本中分析了FAPα活性和水平.
同时测量了原循环标记物 (PINP,PIIINP,CTx) 和完整的FGF21.
对照组包括非GHD的下垂体患者和健康个体.

主要成果:

在GHD患者中,GH替代显著增加了FAPα活性和水平 (分别P <.05和P <.01).
原循环标记 (PINP,PIIINP,CTx) 在GH治疗3个月后也显著增加.
在整个研究期间,完整的FGF21水平保持不变.

结论:

在体内给予GH,首次刺激了人类的FAPα活性.
增加的FAPα活性,以及原的循环,表明GH驱动的原分解和潜在的纤维化.
FAPα成为GH/IGF-I活性的一种新生物标志物,可能与GH诱导的纤维化有关.

关键词:

FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21 纤维细胞激活蛋白质的激活蛋白质国际分支基金 (IGF-I) 的第一部分.原蛋白是一种原蛋白.增长激素增长激素的使用方法生长激素缺乏,生长激素缺乏.

更多相关视频

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Published on: July 29, 2019

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Published on: June 30, 2023

相关概念视频

Introduction to Fibroblasts

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...