慢性压力和IL-10介导的免疫调节循环在牙周炎的发病过程中
Maksym Skrypnyk1,2,3,4, Axel Spahr5, Shlomo Berkovsky1
1Centre for Health Informatics, Australian Institute of Health Innovation, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia.
Clinical science (London, England : 1979)
|November 25, 2025
概括
心理压力通过免疫调节影响牙周病. 介质蛋白-10 (IL-10) 具有双重作用,影响应激反应,并可能减轻牙周炎的骨损失.
科学领域:
- 神经内分泌学神经内分泌学
- 免疫学 免疫学 免疫学
- 口腔生物学 口腔生物学
背景情况:
- 牙周炎是一种慢性炎症性疾病,会损害牙支组织.
- 心理压力越来越多地与牙周炎的发病和通过免疫失调的进展有关.
- 垂体-垂体-上腺 (HPA) 轴和交感-上腺髓 (SAM) 系统是应激反应的关键途径.
研究的目的:
- 审查神经内分泌通路,将心理压力与牙周健康联系起来.
- 探索皮质醇和互白素-10 (IL-10) 在牙周炎中的作用.
- 为了澄清系统性压力如何影响周期性质的局部炎症变化.
主要方法:
- 文献综述综合神经内分泌学,免疫学和口腔生物学.
- 在牙周炎中分析HPA轴作用因子 (皮质醇,IL-10).
- 检查IL-10表达调节性B细胞及其在骨质损失中的作用.
主要成果:
- 压力激活HPA和SAM系统,释放皮质醇,上腺素,上腺素和细胞因子.
- 介质蛋白-10 (IL-10) 具有双重作用:调节应激反应和调节周期性细胞中的免疫反应.
- IL-10影响CRH/ACTH释放和皮质醇分泌,可能减轻膜骨损失.
结论:
- 系统性应激反应有助于牙周炎的局部炎症变化.
- 了解压力,皮质醇和IL-10之间的相互作用为早期诊断和干预提供了潜力.
- 准IL-10通路可能为压力加剧的牙周炎提供新的治疗策略.
相关概念视频
T Cell Types and Functions
2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
Inflammatory Response
15.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.9K
Psychoneuroimmunology: Diabetes and Cancer
417
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
417
Psychoneuroimmunology: Cardiovascular Disease
372
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
372
Hypothalamic-Pituitary Axis
65.4K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
65.4K


