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在Caco-2细胞暴露于未消化的和已消化的二氧化纳米颗粒时,全基因组甲基化变化发生

Célia Ventura1,2, Ana Valente1,2, Luís Vieira1,2

  • 1Department of Human Genetics, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal.

Epigenomics
|November 25, 2025
PubMed
概括

二氧化纳米颗粒 (TiO2NPs) 暴露会改变肠道细胞中的DNA甲基化,影响基因表达和细胞通路. 这些效应根据纳米粒子特性和消化状态而有所不同,这凸显了甲基化在纳米毒理学中的重要性.

关键词:
通过DNA甲基化.基因本体学 基因本体学纳米材料的使用方法路径分析 路径分析模拟消化过程中的消化.

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