怀孕期间25-基维生素D [25(OH) D3] 缺乏在第一季度与产科并发症的增加有关,尽管在怀孕期间服用标准补充剂
Gynecologic and obstetric investigation
|November 25, 2025
概括
孕妇在第一季度维生素D的不足与产科并发症的减少有关,即使在后期补充时也是如此. 早期查和个性化维生素D策略对于最佳的孕产妇和胎儿健康至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 营养科学 营养科学
背景情况:
- 怀孕期间的维生素D缺乏与不良的母胎结局有关.
- 标准补充剂对变化的基线25-基维生素D [25(OH) D3]水平的影响尚不清楚.
- 怀孕早期的维生素D状况可能会影响产科结果.
研究的目的:
- 为了确定第一季度25-基维生素D [25(OH) D3]水平是否会影响接受标准补充剂的孕妇的产科结果.
- 为了比较与怀孕相关的疾病,在妇女之间有足够的和不足的第一季度25(OH) D3水平.
- 根据维生素D状况确定不良产科结果的预测因子.
主要方法:
- 在墨西哥东北部 (2022-2024) 进行了303名孕妇 (年龄为16-50岁) 的回顾性比较队列研究.
- 参与者按第一季度血清25(OH) D3水平 (≥30 ng/mL与<30 ng/mL) 分组,所有参与者每天接受4000 IU补充剂.
- 统计分析包括t测试,曼-惠特尼U测试,奇平方测试和多变量逻辑回归.
主要成果:
- 在怀孕第一季度25(OH) D3度足够的妇女在整个怀孕期间保持更高的度,相比于后来达到充足度的妇女 (p<0.001).
- 在充足组中观察到更低的孕前 (1.3%与10.6%相比),妊娠糖尿病 (8.6%与24.5%相比),早产 (0%与5.3%相比),尿路感染 (4.6%与14.6%相比) 和细菌性阴道炎 (3.9%与13.2%) 的发病率.
- 第一个季度的25(OH) D3度独立地保护不良结果 (OR=0.21,p<0.001).
结论:
- 第一个三个月的维生素D不足与产科并发症的风险显著降低有关.
- 即使维生素D缺乏症在怀孕后期得到纠正,早期的维生素D不足也会带来保护性益处.
- 这些发现强调了早期维生素D查和个性化补充策略在受孕前的重要性,以优化孕产妇和胎儿的健康.
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