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纹身墨水诱发了淋巴结排水的炎症,并改变了对疫苗接种的免疫反应

Arianna Capucetti¹, Juliana Falivene^1,2, Chiara Pizzichetti^1,3

¹Infection and Immunity Laboratory, Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500, Switzerland.

Proceedings of the National Academy of Sciences of the United States of America

|November 25, 2025

概括

纹身墨水进入淋巴结,免疫细胞在那里捕获它,导致炎症和亡. 这种积累改变了疫苗的反应,可能会影响公共卫生.

科学领域:

免疫学免疫学免疫学
毒理学毒理学毒理学
淋巴系统研究淋巴系统研究

背景情况:

纹身是一种流行的做法,安全问题越来越严重.
纹身墨水对免疫系统的影响在很大程度上仍未被研究.
了解纹身墨水在人体中的旅程对于公共健康至关重要.

研究的目的:

研究纹身油墨在淋巴系统中的运输和积累.
为了描述纹身油墨暴露后的免疫反应.
评估纹身墨水对疫苗疗效的影响.

主要方法:

利用一种小鼠模型来追踪纹身油墨的分布.
分析了免疫细胞的反应,包括炎症和亡.
疫苗接种后评估抗体的产生和免疫细胞的表达.

主要成果:

纹身墨水很快被运送到淋巴结,并被巨细胞捕获.
墨水的积累会引发持续的局部和全身炎症.
巨捕获的墨水诱导人类和小鼠细胞的亡.
纹身墨水暴露会调节对mRNA SARS-CoV-2和非活化流感疫苗的免疫反应.
使用mRNA SARS-CoV-2疫苗观察到抗体反应的减少,使用非活化流感疫苗观察到增强反应.

结论:

纹身导致淋巴结中的油墨积累,导致炎症和亡.
淋巴结中纹身墨水的存在可以显著改变疫苗的有效性.
研究结果强调了纹身对免疫功能和疫苗反应的潜在风险.
结果为毒理学,政策和关于纹身安全的公众意识提供了信息.

关键词:

接种Covid疫苗的人群免疫毒理学免疫毒理学这是一种炎症炎症炎症炎症.

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