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孕产妇呼吸道同胞性病毒疫苗接种和早产:犹他州全州的回顾性队列研究

Amy M Solsman¹, Torri D Metz, Josh Benton

¹Utah Department of Health and Human Services, the University of Utah Health, the Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Utah, the Spencer Fox Eccles School of Medicine, and the Primary Children's Hospital, Salt Lake City, Utah.

Obstetrics and gynecology

|November 25, 2025

概括

母亲接种呼吸道同胞病毒 (RSV) 疫苗与早产的几率降低有关. 该RSV疫苗在怀孕期间显示出安全性,没有不良分娩结果,保护新生儿免受严重的呼吸道疾病.

科学领域:

产科和妇科产科和妇科
新生儿健康新生儿健康
疫苗学疫苗学疫苗学

背景情况:

过早分娩仍然是新生儿发病率和死亡率的主要原因.
呼吸道同胞性病毒 (RSV) 对婴儿构成重大威胁,导致严重的下呼吸道疾病.
孕产妇免疫是保护新生儿免受传染病的一种策略.

研究的目的:

评估孕妇在怀孕期间接种母体呼吸道同胞病毒 (RSV) 疫苗和早产发病率之间的关联.
评估RSV疫苗在孕妇中的安全性概况及其对不良分娩结果的影响.

主要方法:

在犹他州进行了一项回顾性队列研究,包括在怀孕32 0/7至36 6/7周之间分娩单独新生儿的个人.
数据从2023年9月到2024年2月收集,并跟踪到交付.
分析了与早产和其他新生儿不良结果相关的母亲RSV疫苗接种情况.

主要成果:

总体而言,24,213人中有11.3%的人接种了RSV疫苗.
接受RSV疫苗的母亲与早产的几率显著降低 (aOR 0.80,95% CI 0.67-0.95).
没有任何不良出生结果,包括高血压疾病,低出生体重或胎儿/婴儿死亡与RSV疫苗接种有关.

结论:

母亲RSV疫苗接种与早产风险降低有关.
在怀孕期间使用RSV疫苗是安全的,没有发现对出生结果的不良影响.
这些发现支持母体RSV免疫作为新生儿防治严重呼吸道疾病的保护措施.

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